Buy Metronidazole Gel 1
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of metronidazole topical gel in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.
buy metronidazole gel 1
Your doctor may prescribe metronidazole suppositories if you have difficulty swallowing medicines. You'll usually use them 3 times a day. Follow the instructions that come in the packaging with your medicine.
If you need to take several doses of metronidazole a day, try to space them evenly. For example, if you take your medicine 3 times a day, this could be first thing in the morning, mid-afternoon, and at bedtime.
If you forget to take a dose of metronidazole tablets, liquid or suppositories, take it as soon as you remember, unless it's nearly time for your next dose. In this case, just leave out the missed dose and take your next dose at the usual time.
If you're prescribed metronidazole cream or gel for rosacea, you'll normally use it twice a day for about 2 months. Treatment can sometimes last longer. Follow the instructions from your doctor or pharmacist.
If you forget to use metronidazole cream or gel, put it on as soon as you remember, unless it's nearly time for your next dose. In this case, just leave out the missed dose and use your next dose at the usual time.
If you forget to use metronidazole vaginal gel, use it as soon as you remember, unless it's nearly time for your usual dose. In this case, skip the missed dose and use your next dose at the usual time.
This medication is used on the skin to treat a certain skin disorder known as rosacea, a type of adult acne. It may help to decrease redness, swelling and the number of pimples caused by rosacea.This medication is an antibiotic. For the treatment of rosacea, metronidazole is believed to work by decreasing swelling (inflammation). Some brands of this medication also contain sunscreens (see also Notes section).
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions Before using metronidazole, tell your doctor or pharmacist if you are allergic to it; or to other nitroimidazole antibiotics (such as tinidazole); or to other ingredients in this product; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Sun exposure can worsen rosacea. Limit exposure to the sun by wearing a wide-brimmed hat and using a sunscreen that is SPF 15 or greater. If your brand already contains a sunscreen, you should use a regular sunscreen (without the metronidazole) on areas of skin not treated with this medication.
Topical therapy for rosacea aims to reduce inflammatory lesions and decrease erythema but can carry side effects such as stinging, pruritus, and burning. Metronidazole and azelaic acid gel 15% are U.S. Food and Drug Administration-approved for the treatment of rosacea. The current study was conducted to assess the cumulative irritation potential of 2 formulations of metronidazole 0.75% gel and 1% gel--and azelaic acid gel 15% over 21 days (N=36). Results of this study demonstrated a significantly greater poten tial for irritation from azelaic acid compared with metronidazole gel 0.75% (P
You will know that metronidazole gel is working if symptoms, such as a fishy smell or watery discharge, begin to clear up in 2 to 3 days. If you finish your full 5 day course and still have symptoms, then the treatment may not have been effective and you should speak to a doctor. You may need to try a different treatment.
Although metronidazole gel is usually prescribed for 5 days, in some cases, you may have to take more treatment for bacterial vaginosis symptoms to go. Your doctor will advise you on this, as they may prescribe a different kind of treatment to treat bacterial vaginosis.
If you forget to use metronidazole gel one night, you must not take a double dose to make up for it. Simply apply the gel at your next bedtime. You must follow the full course of metronidazole gel through, as the infection may not go completely otherwise.
Although it is a common side effect of metronidazole gel, treatment can cause thrush, which is a thick, white vaginal discharge which may or may not have an odour. This may go away soon after you have finished your full course of treatment, or you may need further treatment.
If you get any common or uncommon side effects of metronidazole gel, they will normally go before or soon after treatment has ended. Should you still have symptoms, you should talk to your doctor. If you get serious side effects of metronidazole gel, you should go to your A&E.
If you are pregnant or thinking of having a baby soon, you should ask your doctor or pharmacist for advice before you take metronidazole gel. While metronidazole gel is thought to be safe to use while pregnant, it is only recommended if your doctor or pharmacist says so.
If you drink alcohol while using metronidazole gel for bacterial vaginosis, this can make you feel or be sick. You may also get headaches, become confused, and your heartbeat may rise. You should not drink alcohol while taking metronidazole gel.
You can take painkillers like paracetamol during metronidazole gel treatment. Although no interactions have been found between paracetamol and metronidazole gel, you should still speak to your doctor first before using.
METROGEL contains metronidazole, USP. Chemically, metronidazole is 2-methyl-5-nitro-1 H-imidazole-1-ethanol. The molecular formula for metronidazole is C6H9N3O3. It has the following structural formula:
METROGEL is an aqueous gel; each gram contains 10 mg of metronidazole in a base of betadex, edetate disodium, hydroxyethyl cellulose, methylparaben, niacinamide, phenoxyethanol, propylene glycol, propylparaben and purified water.
The following adverse reaction has been identified during post- approval use of topical metronidazole. Because this reaction is reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate the frequency or establish a causal relationship to drug exposure.
Oral metronidazole has been reported to potentiate the anticoagulant effect of coumarin and warfarin, resulting in a prolongation of prothrombin time. Drug interactions should be kept in mind when METROGEL is prescribed for patients who are receiving anticoagulant treatment, although they are less likely to occur with topical metronidazole administration because of low absorption.
Peripheral neuropathy, characterized by numbness or paresthesia of an extremity, has been reported in patients treated with systemic metronidazole. Peripheral neuropathy has been reported with the post approval use of topical metronidazole. The appearance of abnormal neurologic signs should prompt immediate reevaluation of METROGEL therapy. Metronidazole should be administered with caution to patients with central nervous system diseases.
Available data have not established an association with metronidazole use during pregnancy and major birth defects, miscarriage or other adverse maternal or fetal outcomes. No fetotoxicity was observed after oral administration of metronidazole in pregnant rats or mice. The available data do not allow the calculation of relevant comparisons between the systemic exposures of metronidazole observed in animal studies to the systemic exposures that would be expected in humans after topical use of METROGEL.
It is not known whether metronidazole is present in human milk after topical administration. Published literature reports the presence of metronidazole in human milk after oral administration. There are reports of diarrhea and candida infection in breastfed infants of mothers receiving oral treatment with metronidazole. There are no data on the effects of metronidazole on milk production. Because of the potential for serious adverse reactions, advise patients that breastfeeding is not recommended during treatment with METROGEL.
The pharmacodynamics of metronidazole in association with the treatment of rosacea are unknown. Cardiac Electrophysiology: The effect of METROGEL on the QTc interval has not been adequately characterized.
Topical administration of a one-gram dose of METROGEL to the face of 13 subjects with moderate to severe rosacea once daily for 7 days resulted in a mean + SD Cmax of metronidazole of 32 + 9 ng/mL. The mean + SD AUC(0-24) was 595 + 154 ng*hr/mL. The mean Cmax and AUC(0-24) are less than 1% of the value reported for a single 250 mg oral dose of metronidazole. The time to maximum plasma concentration (Tmax) was 6-10 hours after topical application.
The Centers for Disease Control and Prevention (CDC) released new guidelines for the treatment of sexually transmitted diseases (STDs) in 1998. Several treatment advances have been made since the previous guidelines were published. Part II of this two-part series on STDs describes recommendations for the treatment of diseases characterized by vaginal discharge, pelvic inflammatory disease, epididymitis, human papillomavirus infection, proctitis, proctocolitis, enteritis and ectoparasitic diseases. Single-dose therapies are recommended for the treatment of several of these diseases. A single 1-g dose of oral azithromycin is as effective as a seven-day course of oral doxycycline, 100 mg twice a day, for the treatment of chlamydial infection. Erythromycin and ofloxacin are alternative agents. Four single-dose therapies are now recommended for the management of uncomplicated gonococcal infections, including 400 mg of cefixime, 500 mg of ciprofloxacin, 125 mg of ceftriaxone or 400 mg of ofloxacin. Advances in the treatment of bacterial vaginosis also have been made. A seven-day course of oral metronidazole is still recommended for the treatment of bacterial vaginosis in pregnant women, but intravaginal clindamycin cream and metronidazole gel are now recommended in nonpregnant women. Single-dose therapy with 150 mg of oral fluconazole is a recommended treatment for vulvovaginal candidiasis. Two new topical treatments, podofilox and imiquimod, are available for patient self-administration to treat human papillomavirus infection. Permethrin cream is now the preferred agent for the treatment of pediculosis pubis and scabies. 041b061a72